The continuous spread and the intensifying outbreaks of mosquito-borne orthoflaviviruses are becoming a growing global concern. These viruses, including dengue, Zika, and yellow fever, cause severe diseases and can trigger widespread epidemics, with dengue alone infecting over 400 million people annually. Factors such as climate change, globalization, and the proliferation of invasive mosquito species have contributed to the worldwide dissemination of these pathogens. In Europe, the range of Aedes mosquitoes, vectors for some of these viruses, is expanding by approximately 100 km per year. Recently, Europe has witnessed an upsurge in cases of West Nile virus (WNV) and Usutu virus (USUV) infection, both transmitted by Culex mosquitoes. In 2024, the largest geographical distribution of WNV in Europe in a single year was observed, with 1436 human cases of WNV infection, with 91%  of cases hospitalized and 9% case fatality rate.